U Frank (CN),У Франк (CN),CHEN Bo (CN),ЧЭНЬ Бо (CN)
申请号：
RU2016130986
公开号：
RU0002670762C2
申请日:
2014.12.30
申请国别(地区):
RU
年份:
2018
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to organic chemistry, specifically to 6-(pyrimidinoamino-pyridine)benzoimidazole derivatives of formula (I') or a stereoisomer thereof, wherein A1 and A2 are independently selected from nitrogen； R1 is selected from C1-6alkyl； R2 is selected from C1-6alkyl； R3 and R5 are independently selected from halogen； R4 is selected from a nitrogen-containing 5–6 membered heterocyclyl, optionally substituted with Q2, where the nitrogen-containing 5–6 membered heterocyclyl is a nitrogen-containing 5–6 membered heterocyclyl containing 1 to 2 nitrogen atoms； a nitrogen-containing 7–9 membered bridged heterocyclyl optionally substituted with Q2, where the nitrogen-containing 7–9 membered bridged heterocyclyl is a nitrogen-containing 7–9 membered bridged heterocyclyl containing 1 to 2 nitrogen atoms； 6–10-membered fused heterocyclyl which contains 1, 2 or 3 identical or different heteroatoms and is optionally substituted with Q2, wherein the heteroatoms are selected from a nitrogen atom and an oxygen atom, and comprise at least one nitrogen atom； a nitrogen-containing 7–11-membered spiro-heterocyclyl, optionally substituted with Q2, where the nitrogen-containing 7-11-membered spiro-heterocyclyl is a nitrogen-containing 7-11 membered spiro-heterocyclyl containing 1 to 2 nitrogen atoms； Q2 is selected from amino or di-C1-6alkylamino； or from C1-6alkyl, 3-8-membered cycloalkyl, oxacyclobutanyl, nitrogen-containing 5-6 membered heterocyclyl, or a nitrogen-containing 8-membered bridged heterocyclyl, each of which is optionally substituted with a substituent, wherein the substituent is selected from C1-6alkyl and 3-8 membered cycloalkyl； n is selected from 0, 1. Invention also relates to a pharmaceutical composition capable of inhibiting the activity of CDK4 and/or CDK6 kinases based on a compound of formula (I').EFFECT: technical result is novel compounds useful for reducing or inhibiting the activity of CDK4/6 kinase in a cell and/or in the
