Provided herein are T cell receptor (TCR) fusion proteins (TFPs), T cells engineered to express one or more MUC16 or IL13Rα2 or MSLN TFPs, and methods of use thereof for the treatment of diseases, including cancer.本文中提供T細胞受體(TCR)融合蛋白(TFP)、經工程化以表現一或多種MUC16或IL13Rα2或MSLN TFP之T細胞及其用於治療疾病,包括癌症之使用方法。