New identification problem and this disease of conventional therapy and bed-wetting overactive bladder are not that simply, due to dysfunction detrusor urinae of bladder smooth muscle, but complicated disorder includes the interaction between feeling and kinesitherapy nerve. Therefore, although individually can be used for some women using anti-muscarinic agents, it has been found that use processing therapeutic agent mixed active anticholinergic activity can be it is particularly useful. In addition, impacted across cellular layer due to absorbing the drug, by fat-soluble drug, the present invention also optionally includes adjusting to form drug to relative concentration (polarity) electrification and uncharged (nonpolarity) that influence suppository.