Jerome Kalifa;Raoul Kopelman;Yong-Eun Koo Lee;Uma Mahesh R. Avula;Gwangseong Kim;Hyung Ki Yoon;THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人:
Jerome Kalifa,Raoul Kopelman,Uma Mahesh R. Avula,Gwangseong Kim,Yong-Eun Koo Lee,Hyung Ki Yoon
申请号：
US14396533
公开号：
US10512691B2
申请日:
2013.04.23
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention relates to nanoparticles. In particular, the present invention provides nanoparticles for clinical (e.g., targeted therapeutic), diagnostic (e.g., imaging), and research applications in the field of cardiology. For example, in some embodiments, the present invention provides a method of treating (e.g., ablating) cardiac tissue, comprising: a) contacting an animal with a nanoparticle comprising a matrix, a toxic (e.g., ablative) agent (e.g., sonosensitizer, chemotherapeutic agent (e.g., doxorubicin or cisplatin), or photosensitizer), and a cardiac targeting moiety； and b) administering an activator of the toxic agent (e.g., light, chemical (e.g., pharmaceutical agent) or ultrasound) to at least a portion of the cardiac tissue (e.g., heart) of the animal to activate the toxic agent.
