2-(5-{1-[2-(Difluoromethoxy)-6-fluorobenzyl]-2-methyl-1H- benzimidazol-6- yl}pyrimidin-2-yl)propan-2-ol, or a pharmaceutically acceptable salt thereof, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.2-(5-{1-[2-(Difluorometoxi)-6-fluorobencil]-2-metil-1H-bencimidaz ol-6-il}pirimidin-2-il)propan-2-ol, o una sal farmacéuticamente aceptable del mismo, que son potentes moduladores de la actividad del TNFa humano, son por lo tanto beneficiosos en el tratamiento y/o prevención de diversas dolencias humanas, incluyendo trastornos autoinmunes e inflamatorios; trastornos neurológicos y neurodegenerativos; dolor y trastornos nociceptivos; trastornos cardiovasculares; trastornos metabólicos; trastornos oculares; y trastornos oncológicos.