<;P>;PROBLEM TO BE SOLVED: To provide a material for inhibiting autoinducer-2, and to provide a material effective for prevention and/or treatment of an infectious disease. <;P>;SOLUTION: The autoinducer-2 inhibitor includes a compound represented by formula I (wherein, R<;SP>;1<;/SP>;and R<;SP>;2<;/SP>;are each independently hydrogen, a hydroxy group, an aryl group or an alkoxy group, or form an oxo group by bonding to each other; R<;SP>;3<;/SP>;is a halogen; and R<;SP>;4<;/SP>;is hydrogen, an amino group or a halogen) or a salt thereof as an active ingredient. The agent for preventing and/or treating the infectious disease includes the compound or the salt thereof as an active ingredient. <;P>;COPYRIGHT: (C)2009,JPO&INPIT