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NOVEL DEUTERIUM SUBSTITUTED POSITRON EMISSION TOMOGRAPHY (PET) IMAGING AGENTS AND THEIR PHARMACOLOGICAL APPLICATION
专利权人:
Five Eleven Pharma Inc.
发明人:
Zehui WU,Zhihao ZHA,Futao LIU,Karl PLOESSL,Seok Rye CHOI,Hank F. KUNG
申请号:
US15994474
公开号:
US20180344882A1
申请日:
2018.05.31
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present invention relates to deuterated compounds according to Formula I-A, Formula II-A, Formula II-D, and Formula III-A. These compounds can be used as PET imaging agents for evaluating Parkinson's Disease, Alzheimer Disease, and for determining specific serotonin reuptake inhibitor (SSRIi) activity for treatment of depression. The present invention also relates to pharmaceutical compositions comprising a pharmaceutical acceptable carrier and a compound of Formula I-A, Formulae II-A, Formula II-D, or Formula III-A, or a pharmaceutically acceptable salt thereof.
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