The invention relates to substituted spirocyclic cyclohexane derivatives which have an affinity for the μ opioid receptor and the ORL1 receptor, processes for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.本發明係關於對μ-型類鴉片受體和類鴉片孤兒受體(ORL1)具有親和性之被取代之螺環環己烷衍生物,及其製備方法,含有上述化合物之藥品,及上述化合物用於製備藥品之用途。