Centre National de la Recherche Scientifique (CNRS);Institute National de la Sante et de la Recherche Medicale (INSERM);Universite Paris Descartes
发明人:
Sandrine Bourdoulous,Kévin Denis,Loïc Le Guennec
申请号：
US16628687
公开号：
US20200222418A1
申请日:
2018.07.06
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention provides a phenothiazine derivative of formula (I) for use in preventing and/or treating infection caused by bacteria carrying Type IV pili, such as N. meningitidis, and more specifically for use in preventing and/or treating meningitis. The present invention further relates to a composition for the use in preventing and/or treating infection caused by bacteria carrying Type IV pili, such as purpura fulminans and meningitis, comprising a phenothiazine derivative of formula (I) and an antibiotic selected from the group consisting of beta-lactams and aminoglycosides, and/or dexamethasone.
