The invention provides a composition for treating dermatosis. The composition comprises unsaturated fatty acid, collagen, amino acid, vitamin and inorganic salt. The invention further provides various preparations prepared by the addition of an excipient into the composition and a preparation method thereof. The composition and its preparation provided by the invention have remarkable effects in clinic experiments and have substantial curative effects for treating dermatosis such as neurodermatitis (psoriasis), whelk, manus and tinea pedis, tinea unguium, corn, paronychia and the like in a short time.
