Andrey Loboda,Michael Nebozhyn,Alexei Podtelezhnikov,David J. Stone,Keith Tanis,William J. Ray
申请号：
US14354622
公开号：
US20140304845A1
申请日:
2012.10.26
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Methods, biomarkers, and expression signatures are disclosed for assessing the disease progression of Alzheimers disease (AD). In one embodiment, BioAge (biological age), NdStress (neurodegenerative stress), Alz (Alzheimer), and Inflame (inflammation) are used as biomarkers of AD progression. In another aspect, the invention comprises a gene signature for evaluating disease progression. In still another embodiment, methods for evaluating disease progression are provided. In yet another embodiment, the invention can be used to identify animal models for use in the development and evaluation of therapeutics for the treatment of AD.
