This invention generally, the deformans arthropathy (OA) regards remedy and/or prevention. According to this invention, the competition glaze of GM CSF can become effective by the remedy of the deformans arthropathy. It does not limit the competition glaze of GM CSF, but the unique antibody is included in the GM CSF or GM CSF receptor. This invention furthermore although the competition glaze is tested in the diseased model of specification the usefulness, offers the gene introduction animal such as the GM CSF knockout mouse.< Choice figure >It is not本発明は一般的には、変形性関節症(OA)の治療及び/又は予防に関する。本発明によると、GM-CSFの拮抗薬は変形性関節症の治療に有効となりうる。GM-CSFの拮抗薬は限定しないが、GM-CSF又はGM-CSF受容体に特異的な抗体を含む。本発明は更に、特定の疾患モデルにおいて拮抗薬を試験するのに有用な、GM-CSFノックアウトマウスといった遺伝子導入動物を提供する。【選択図】なし
