Timothy A. Blizzard,Helen Chen,Candido Gude,Jeffrey D. Hermes,Jason Imbriglio,Seongkon Kim,Jane Y. Wu,Christopher J. Mortko,Ian Mangion,Nelo Rivera,Rebecca T. Ruck,Michael Shevlin
申请号：
US12812763
公开号：
US08487093B2
申请日:
2009.01.15
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Substituted bicyclic beta-lactams of Formula I: (I), are β-lactamase inhibitors, wherein a, X, R1 and R2 are defined herein. The compounds and pharmaceutically acceptable salts thereof are useful in the treatment of bacterial infections in combination with β-lactam antibiotics. In particular, the compounds can be employed with a β-lactam antibiotics (e.g., imipenem, piperacillin, or ceftazidime) against microorganisms resistant to β-lactam antibiotics due to the presence of the β-lactamases.
