The invention relates to a pharmaceutical preparation comprising a) a core with an active ingredient and with an organic acid and/or with the salt of an organic acid； b) a coating which surrounds the core and which comprises content of polymer composed of (meth)acrylate copolymers having no more than 15% by weight of cationic or anionic groups, and which comprises at least 60% by weight of a (meth)acrylate copolymer which is composed of free-radical-polymerized units of from 93 to 98% by weight of C1-C4-alkyl esters of acrylic or methacrylic acid and from 7 to 2% by weight of (meth)acrylate monomers having a quaternary ammonium group in the alkyl radical, characterized in that the water-solubility of the active ingredient is at least 10 g/l at 20°C and the coating comprises silicon dioxide particles whose average particle size is in the range from 1 to 50 mm.
