CHRISTOPH LADEL,GERALD BESTE,HANS GUEHRING,LARS TOLEIKIS,RALF GUENTHER,ROLAND KELLNER,SOREN STEFFENSEN,SVEN LINDEMANN
申请号：
BR112019025147
公开号：
BR112019025147A2
申请日:
2018.06.04
申请国别(地区):
BR
年份:
2020
代理人:
摘要：
the present invention relates to polypeptides that bind aggrecan, as well as adamts5 and / or mmp13, more specifically to polypeptides that comprise or essentially consist of immunoglobulins that bind aggrecan, as well as immunoglobulins that bind adamts5 and / or immunoglobulins that bind mmp13 ( also referred to herein as "polypeptides of the invention" and "immunoglobulin (s) of the invention", respectively). the invention also relates to constructs comprising such immunoglobulins, as unique immunoglobulin variable domains (isvds) or polypeptides, as well as nucleic acids encoding such immunoglobulins or polypeptides (also referred to herein as "the nucleic acid of the invention"； to methods for preparing such immunoglobulins, polypeptides and constructs； host cells that express or are capable of expressing such immunoglobulins or polypeptides； to compositions and, in particular, pharmaceutical compositions comprising such immunoglobulins, polypeptides, constructs, nucleic acids and / or host cells； and to uses immunoglobulins, polypeptides, constructs, nucleic acids, host cells and / or compositions, in particular for prophylactic and / or therapeutic purposes, such as the prophylactic and / or therapeutic purposes mentioned herein.other aspects, modalities, advantages and applications of the invention will remain clear from the additional description here.a presente invenção refere-se a polipeptídeos que ligam aggrecan, bem como a adamts5 e/ou mmp13, mais especificamente a polipeptídeos que compreendem ou consistem essencialmente em imunoglobulinas que ligam aggrecan, bem como imunoglobulinas que ligam adamts5 e/ou imunoglobulinas que ligam mmp13 (também aqui referidos como "polipeptídeos da invenção" e "imunoglobulina (s) da invenção", respectivamente). a invenção também se refere a construtos compreendendo essas imunoglobulinas, como domínios variáveis únicos de imunoglobulina (isvds) ou polipeptídeos, bem como ácidos nucleicos que codificam essas imunoglobul
