In alternative embodiments, provided are compositions, including therapeutic combinations of drugs, and methods of using them for e.g., treating, ameliorating and preventing various bacteria-induced conditions, disorders and infections in mammals, including genetically-predisposed and chronic disorders. In alternative embodiments, methods using the therapeutic combinations of drugs such as antibiotics, as provided herein, comprise or comprise use of medications, formulations and pharmaceuticals comprising active agent combinations as provided herein to e.g., treat, ameliorate, suppress or prevent a bacteria-induced condition, disorder or infection in a mammal. These therapeutic combinations of drugs, including medications, formulations and pharmaceuticals, are effective in a broad spectrum of disorders, including e.g., a skin or skin-related autoimmune disease or condition, e.g., a psoriasis.
