Joseph A. Zasadzinski,Norbert O. Reich,Gary B. Braun,Demosthenes P. Morales,Xiao Huang
申请号：
US15830898
公开号：
US20180078612A1
申请日:
2017.12.04
申请国别(地区):
US
年份:
2018
代理人:
摘要：
This disclosure describes, in one aspect, a composition for intracellular delivery of a polypeptide. Generally, the composition includes a substrate that has a surface, a cleavable linker affixed to at least a portion of the surface, and a cargo polypeptide bound to the cleavable linker. In some embodiments, the cargo polypeptide can further include a targeting peptide. In another aspect, this disclosure describes a method for intracellular delivery of a polypeptide. Generally, the method includes administering to a subject any embodiments of the composition summarized above, and cleaving the cleavable linker, thereby releasing the cargo polypeptide from the substrate.
