PROBLEM TO BE SOLVED: To provide a preventive or therapeutic agent of retinochoroidal degeneration disorders, for example, atrophic age-related macular degeneration, pigmentary retinal dystrophy, gyrate atrophy of choroid and retina, as well as retinochoroidal disorders resulting from the diseases.SOLUTION: This compound represented by general formula (1) or its salt has an inhibitory effect for optical receptor cell death and/or visual cell death in a mouse optical disorder model. Therefore, it is useful for the preventive or therapeutic agent of the retinochoroidal degeneration disorders such as atrophic age-related macular degeneration, pigmentary retinal dystrophy, gyrate atrophy of choroid and retina, as well as retinochoroidal disorders resulting from the diseases.COPYRIGHT: (C)2012,JPO&INPIT【課題】実質的に新生血管を伴わない網脈絡膜変性疾患、たとえば、萎縮型加齢黄斑変性、網膜色素変性症、脳回転状網膜脈絡膜萎縮症、さらにはそれらの疾患に伴う網脈絡膜障害の予防または治療剤を提供すること。【解決手段】一般式(1)で表される化合物またはその塩は、マウス光障害モデルにおける、光受容体細胞死および/または視細胞死に対して抑制効果を有する。よって、実質的に新生血管を伴わない網脈絡膜変性疾患、たとえば、萎縮型加齢黄斑変性、網膜色素変性症、脳回転状網膜脈絡膜萎縮症、さらにはそれらの疾患に伴う網脈絡膜障害の予防または治療剤として有用である。【選択図】なし
