Provided are pharmaceutical compositions for vaginal administration and methods of preparing them. The compositions are in the form of rapid dissolve vaginal tablets .The compositions comprise rapid dissolve microgranules comprising: (a) a therapeutically effective amount of a vaginally active drug (b) a polymeric excipient having a dual property of acting as a binder as well as a bioadhesive material (c) a sugar alcohol, a saccharide, or a mixture thereof and (d) a disintegrant wherein said pharmaceutical composition rapidly disintegrates upon insertion into the vaginal cavity of a patient or subject forming a viscous drug-containing suspension that rapidly, widely spreads coating the vaginal mucosa. Examples of the polymeric excipient include low-substituted hydroxyethylcellulose, hydroxypropylcellulose, hypromellose, polycarboxylic acids, polyvinylpyrrolidone, vinylpyrrolidone-polyvinyl acetate copolymer, ethylene glycol 6000 - vinylcaprolactam - vinyl acetate copolymer, polyvinyl alcohol, polyethylene oxide, poly(lactic co-glycolic acid), polyamide, alginic acid salts, carrageenan, chitosan, and cellulosic gum.
