Martin Wald,Oliver Cromwell,Andreas Nandy,Helga Kahlert,Bernhard Weber,Helmut Fiebig
申请号：
US14146364
公开号：
US09522938B2
申请日:
2014.01.02
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to the preparation and use of variants of the group 5 allergen of the Pooideae which are characterised by reduced IgE reactivity compared with the known wild-type allergens and at the same time by substantially retained reactivity with T lymphocytes. These hypoallergenic allergen variants can be employed for the specific immunotherapy (hyposensitisation) of patients having grass pollen allergy or for the preventative immunotherapy of grass pollen allergies.
