Techniques for performing therapy using an internal anatomy therapy delivery system are described herein. The internal anatomy therapy delivery system calculates a treatment location from sensor data received from an internal anatomy therapy delivery device, determines an appropriate therapy, and moves the internal anatomy therapy delivery device to a location on the anatomical surface corresponding to the therapy. Once at the location, the internal anatomy therapy delivery device determines treatment parameters based on local measurements, delivers the treatment, and makes additional measurements to determine whether the treatment was successful.