KUMAR, SHANKAR,TSO, J. YUN,TSURUSHITA, NAOYA,KON, SHIGEYUKI,UEDE, TOSHIMITSU
申请号：
CA2721716
公开号：
CA2721716C
申请日:
2009.04.24
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The present invention provides humanized antibodies that immunospecificallyrecognize the RGD sequence. Someof these antibodies inhibit the biological functions of the RGD proteins,thereby exhibiting therapeutic effects on various disordersor diseases that are associated with RGD proteins, including cancer, e.g., thegrowth and metastasis of a cancer cell, and inflammatorydiseases, e.g., rheumatoid arthritis, osteoarthritis, hepatitis,endometriosis, bronchial asthma, fibrosis, diabetes, arteriosclerosis,multiple sclerosis, granuloma, an inflammatory bowel disease (ulcerativecolitis and Crohn's disease), an autoimmune disease,and so forth.
