Disclosed is a single-use suture anchor and shaft cartridge, the cartridge being removably attached to a reusable handle. One or more sutures may be secured to the suture anchor and routed through interior cannulations of both the suture anchor and the shaft. The ends of the sutures may then be passed to the outside of the shaft either through an aperture in the shaft or into a communicating cannulation in the handle assembly. The ends of the suture then may be passed to the outside of the handle either through an opening at the proximal end of the handle or through a sidewall opening in the handle.