TECHNISCHE UNIVERSITAT MUNCHEN;STICHTING SANQUIN BLOEDVOORZIENING;NATIONAL UNIVERSITY OF SINGAPORE
发明人:
GROTENBREG, GIJSBERT MARNIX,VERHELST, STEVEN HENDRIK LEONARD,CHOO, AI LING JOANNA,THONG, SOCK YUE,YAP, JIAWEI,VAN ESCH, WILHELMUS JOHANNES ELISABETH
申请号：
CA2951207
公开号：
CA2951207A1
申请日:
2015.06.05
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
In one aspect the invention relates to major histocompatibility complex (MHC) molecules comprising a ligand in the peptide binding groove of the MHC molecule, whereby said ligand comprises an azobenzene (Abc), and at least two amino acid residues separated by the azo-group of the Abc, and wherein the amino acid residues are positioned to interact with the peptide binding groove of the MHC molecule. The invention also relates, among others, to means and methods for producing and using such MHC molecules, and the ligands therefore.
