Sulfonamide compounds having TRPM8 antagonistic activity are provided. A sulfonamide compound of formula (I) or a pharmaceutically acceptable salt thereof, or a prodrug thereof: wherein Ring A is bicyclic aromatic heterocycle comprised of (a) pyridine is condensed with benzene； or (b) pyridine is condensed with monocyclic aromatic heterocycle, and Ring A binds to a sulfonylamino moiety on a carbon atom adjacent to a nitrogen atom of the pyridine ring constituting Ring A, Ring B is (a) monocyclic or bicyclic aromatic hydrocarbon； (b) monocyclic or bicyclic alicyclic hydrocarbon； (c) monocyclic or bicyclic aromatic heterocycle； or (d) monocyclic or bicyclic non-aromatic heterocycle, Ring C is (a) benzene； or (b) monocyclic aromatic heterocycle, and other symbols are the same as defined in the specification.本案提供具有TRPM8拮抗活性之磺醯胺化合物。式(I)之磺醯胺化合物或其醫藥上可接受之鹽、或其前藥：其中環A為包含下列各者之雙環芳香族雜環：(a)與苯縮合之吡啶；或(b)與單環芳香族雜環縮合之吡啶，及環A係以與組成環A的吡啶環之氮原子相鄰的碳原子結合至磺醯胺基部分，環B為(a)單環或雙環之芳香族烴；(b)單環或雙環之環脂族烴；(c)單環或雙環之芳香族雜環；或(d)單環或雙環之非芳香族雜環，環C為(a)苯；或(b)單環芳香族雜環，及其它符號係與說明書中定義相同。
