Compositions et procédés pour inhiber PDGFR-bêta et VEGF-A

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专利权人:

ZymoGenetics; Inc.

发明人:

申请号：

EP13159549.8

公开号：

EP2604279A1

申请日:

2009.03.27

申请国别(地区):

EP

年份:

2013

代理人:

摘要：

There is provided an isolated antibody that binds to VEGF-A and neutralizes VEGF-A activity, said antibody comprising a VL domain comprising CDRs LCDR1, LCDR2 and LCDR3, and a VH domain comprising CDRs HCDR1, HCDR2 and HCDR3, wherein:LCDR1 has the amino acid sequence shown in SEQ ID NO: 448；LCDR2 has the amino acid sequence shown in SEQ ID NO: 449；LCDR3 has the amino acid sequence shown in SEQ ID NO: 450；HCDR1 has the amino acid sequence shown in SEQ ID NO: 451；HCDR2 has the amino acid sequence shown in SEQ ID NO: 452；HCDR3 has an amino acid sequence selected from the group consisting of SEQ ID NOs: 453-461.

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