BASIT, ABDUL WASEH,BRAVO GONZALEZ, ROBERTO CARLOS,BUSER, THOMAS,FREIRE, ANA CRISTINA,GOUTTE, FREDERIC JEAN-CLAUDE,VARUM, FELIPE JOSE OLIVERIA
申请号：
CA3080035
公开号：
CA3080035A1
申请日:
2013.04.29
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Delayed release of a drug to the colon is achieved from a delayed release formulation comprising a core and a coating for the core. The core comprises a drug and the coating comprises an inner layer and an outer layer. The outer layer comprises a mixture of a first polymeric material which is susceptible to attack by colonic bacteria, and a second polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises a third polymeric material which is soluble in intestinal fluid.
