CHRIS HANSON,JESSICA SIMS,LALI K. MEDINA-KAUWE,MICHAEL TAGUAIM,XIAOJIANG CUI
申请号：
BR112016023025
公开号：
BR112016023025A2
申请日:
2015.04.04
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
Disclosed herein are methods of treating cancer in a patient, the method comprising identifying a patient who is resistant to treatment with anti-her2 therapy； and administering to the patient a drug delivery molecule comprising a polypeptide molecule adapted to target and / or penetrate a cell type； a nucleic acid molecule linked to the polypeptide sequence through electrostatic interactions； and a chemical agent non-covalently linked to the nucleic acid sequence. Also disclosed are methods for inducing apoptosis in an anti-her2 therapy-resistant her2 + breast cancer cell, the method comprising contacting the anti-her2 therapy-resistant her2 + breast cancer cell with the drug delivery molecule. further disclosed herein are methods of treating cancer in a patient, the method comprising identifying a patient who is resistant to anti-her2 therapy； and administering to the patient a therapeutically effective amount of a drug delivery molecule comprising a polypeptide molecule adapted to target and / or penetrate a cell type； and a sulfonated corrol molecule linked to the polypeptide sequence. Finally, methods for inducing apoptosis in an anti-her2 therapy resistant her2 + breast cancer cell are disclosed herein, the method comprising contacting the anti-her2 therapy resistant her2 + breast cancer cell with a molecule of drug delivery comprising a polypeptide molecule adapted to target and / or penetrate a cell type； and a sulfonated corrol molecule linked to the polypeptide sequence.são divulgados, neste documento, métodos de tratamento de câncer em um paciente, o método compreendendo a identificação de um paciente que é resistente ao tratamento com uma terapia com anti-her2； e a administração ao paciente de uma molécula de distribuição de droga, que compreende uma molécula de polipeptídeo adaptado para visar e/ou penetrar em um tipo de célula； uma molécula de ácido nucleico ligado à sequência de polipeptídeo através de interações eletrostáticas； e um agente químico li
