Provided herein are antibodies or antigen-binding fragments thereof, e.g., monoclonal antibodies or antigen binding fragments thereof, that specifically bind to ENTPD2 (e.g., human ENTPD2 protein), and methods of using these antibodies or antigen-binding fragments. The present invention also relates to combination therapies comprising an anti-human ENTPD2 antibody or antigen binding fragment and at least one additional therapeutic agent, and methods of using these combination therapies.本文提供了特異性結合ENTPD2(例如人ENTPD2蛋白)的抗體或其抗原結合片段,例如單株抗體或其抗原結合片段,以及使用該等抗體或抗原結合片段之方法。本發明還涉及組合療法,該組合療法包含抗人ENTPD2抗體或其抗原結合片段和至少一種另外的治療劑,以及使用該等組合療法之方法。