PROBLEM TO BE SOLVED: To provide a new dosing regimen for a selective S1P1 receptor agonist.SOLUTION: Provided is a dosing regimen for a selective S1P1 receptor agonist, whereby the selective S1P1 receptor agonist is administered to a subject in such a way that during the initial treatment phase the selective S1P1 receptor agonist is administered at a dose which induces desensitization of the heart wherein the dose is below the target dose, and sustains desensitization of the heart, until no further acute heart rate reduction occurs, followed by dose up-titration to the target dose of the selective S1P1 receptor agonist.COPYRIGHT: (C)2012,JPO&INPIT【課題】選択的S1P1レセプターアゴニストの新規投与法の提供。【解決手段】初期治療期の間においては、選択的S1P1レセプターアゴニストを、心臓の脱感作を惹起する用量、かつ心臓の脱感作を維持する投与頻度にて、さらなる急性の心拍数減少が起こらなくなるまで投与し、当該用量は標的用量未満であり、続いて選択的S1P1レセプターアゴニストの標的用量への用量漸増を行うように、選択的S1P1レセプターアゴニストを対象に投与する、選択的S1P1レセプターアゴニストの投与法。【選択図】なし
