Philip Wilson Howard,Niall Dickinson,Thais Cailleau,Luke Masterson,William Goundry
申请号：
US16826405
公开号：
US20200306243A1
申请日:
2020.03.23
申请国别(地区):
US
年份:
2020
代理人:
摘要：
A conjugate comprising the following topoisomerase inhibitor derivative (A*):with a linker for connecting to a Ligand Unit, wherein the linker is attached in a cleavable manner to the amino residue. The Ligand Unit is preferably an antibody. Also provided is A* with the linking unit attached, and intermediates for their synthesis, as well as the released warhead.
