VACCIN RECOMBINANT CONTRE LE VIRUS DES OREILLONS

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专利权人:

UNIVERSITY OF GEORGIA RESEARCH FOUNDATION; INC.

发明人:

HE, BIAO

申请号：

CA2828229

公开号：

CA2828229A1

申请日:

2012.02.24

申请国别(地区):

CA

年份:

2012

代理人:

摘要：

The present invention provides the complete genomic sequence of the epidemic mumps virus (MuV) strain MuVIowa/us/06. Further, a reverse genetics system was constructed and used to rescue recombinant viral constructs that are attenuated compared to MuVIowa/us/06 and JL vaccine viruses. Such constructs include viral constructs lacking the open reading frame (ORF) of the SH gene (rMuV?SH) and/or incapable of expressing the V protein (rMuV?V).

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