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Compositions and methods for modulating c-kit and PDGFR receptors
专利权人:
Jon Loren;Valentina Molteni;Juliet Nabakka;Zuosheng Liu
发明人:
Zuosheng Liu,Jon Loren,Valentina Molteni,Juliet Nabakka
申请号:
US12629665
公开号:
US08106068B2
申请日:
2009.12.02
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The invention provides compounds of Formula (2), and pharmaceutical compositions thereof,wherein R1, R2, R3, R4 and L are as described herein; as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit, PDGFRα, PDGFRβ, CSF1R, Abl, BCR-Abl, CSK, JNK1, JNK2, p38, p70S6K, TGFβ, SRC, EGFR, trkB, FGFR3, FLT3, Fes, Lck, Syk, RAF, MKK4, MKK6, SAPK2β, BRK, KDR, c-raf or b-raf kinase, or mutant forms thereof.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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