DELUCA, HECTOR F.,CLAGETT-DAME, MARGARET,PLUM, LORI,FLORES, AGNIESZKA,THODEN, JAMES,HOLDEN, HAZEL,GLAGETT-DAME, MARGARET
申请号：
CA3078408
公开号：
CA3078408A1
申请日:
2018.10.16
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
Disclosed are methods of purifying the compound (22E)-(247R)-2-methylene- 22-dehydro-1a,24,25-trihydroxy-19-nor-vitamin D3 to obtain the compound in crystalline form. The methods typically include the steps of dissolving (22E)-(24R)-2-methylene-22- dehydro-1a,24,25-trihydroxy-19-nor-vitamin D3 in a solvent comprising ethyl acetate and hexane to form a solution, allowing crystals of (22E)-(24R)-2-methylene-22-dehydro- 1a,24,25-trihydroxy-19-nor-vitamin D3 to form and precipitate from the solution, and recovering the crystals of (22E)-(24R)-2-methylene-22-dehydro-1a,24,25-trihydroxy-19-nor- vitamin D3 from the solution.
