FERRER COSTA CARLES,VIRGILI BERNADO MARINA,SOLIVA SOLIVA ROBERT,CARCELLER GONZALEZ ELENA
申请号：
NZ60102110
公开号：
NZ601021A
申请日:
2010.12.22
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Disclosed herein is a compound of formula I, wherein the variables are defined in the specification； the use thereof in the treatment of a disease mediated by the histamine H4 receptor, such as an allergic, immunological or inflammatory disease, pain or cancer； and a process for the preparation thereof. Specific embodiments of the compound include: 4-((cyclopropylmethylamino)methyl)-6-(3-(methylamino)azetidin-1-yl)pyrimidin-2-amine, 4-((2-adamantylamino)methyl)-6-(3-(methylamino)azetidin-1-yl)pyrimidin-2-amine, and 4-(((1R,2R,4S)-bicyclo[2.2.1]heptan-2-ylamino)methyl)-6-{ 3-(methylamino)azetidin-1-yl)pyrimidin-2-amine.
