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METHODS OF TREATMENT USING CTLA4 MUTANT MOLECULES
专利权人:
BRISTOL-MYERS SQUIBB COMPANY
发明人:
Robert James PEACH,Joseph Naemura,Peter S. Linsley,Jurgen Bajorath
申请号:
US15668824
公开号:
US20180134764A9
申请日:
2017.08.04
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present invention provides soluble CTLA4 mutant molecules which bind with greater avidity to the CD80 and/or CD86 antigen than wild type CTLA4 or non-mutated CTLA4Ig. The soluble CTLA4 molecules have a first amino acid sequence comprising the extracellular domain of CTLA4, where certain amino acid residues within the S25-R33 region and M97-G107 region are mutated. The mutant molecules of the invention may also include a second amino acid sequence which increases the solubility of the mutant molecule.
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