Ian M. BELL;Brendan M. CROWLEY;Peter J. MANLEY;William D. SHIPE;Merck Sharp &; Dohme Corp.
发明人:
Ian M. Bell,Brendan M. Crowley,Peter J. Manley,William D. Shipe
申请号:
US16646616
公开号:
US20200262826A1
申请日:
2018.09.14
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The present disclosure relates to compounds of formula I that are useful as modulators of 7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation (I).