Zvi Schwartz,Christopher S.D. Lee,Hunter R. Moyer,Barbara D. Boyan
申请号：
US13579632
公开号：
US20130064861A1
申请日:
2011.02.17
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Provided herein according to some embodiments of the invention are methods of inhibiting or preventing calcification of hydrogels. Such methods may include combining the hydrogel with a buffer solution having a pH lower than 7.4 forming a hydrogel by crosslinking alginate in a solution comprising a bisphosphonate compound and/or forming a hydrogel by crosslinking a polyanionic polymer with a polyvalent cation that is not Ca2+. Compositions that may be used in such methods are also provided herein. Also provided herein according to some embodiments of the invention are methods of bone regeneration and/or formation that include administering a hydrogel that does not encapsulate biological material that affects calcification and/or bone formation to an area of a subjects body that is in need of bone formation and/or regeneration.
