This Hair is bright to be related to Yi Seed BTK kinase inhibition Elixirs Knot crystalline form Ji Qi System Prepare method. Ju Body , this Hair it is bright be related to (R) -4- amino -1- (1- (butyl- 2- alkynes acyl group) pyrrolidin-3-yl) -3- (4- (2,6- difluoro phenoxy group) phenyl) -1,Bis- Hydrogen -7H- pyrrolo- of 6- [2,The I Xing Knot crystalline substance of 3-d] Da piperazine -7- ketone (formula (I) compound) is Ji Qi System Prepare method. The I Xing Knot crystalline substance qualitative , And of the tool qualitative Heization Learn Steady of the good crystal form Steady of Prepare and Suo of formula (I) compound obtained by this Hair is bright are stayed Yong the low Disabled of the brilliant molten Elixirs low toxicity of Knot, can preferably Yong Yu Pro control Treatment.本發明涉及一種BTK激酶抑制劑的結晶形式及其製備方法。具體地，本發明涉及(R)‑4‑氨基‑1‑(1‑(丁‑2‑炔酰基)吡咯烷‑3‑基)‑3‑(4‑(2,6‑二氟苯氧基)苯基)‑1,6‑二氫‑7H‑吡咯并[2,3‑d]噠嗪‑7‑酮(式(I)化合物)的I型結晶及其製備方法。本發明所得到式(I)化合物的I型結晶具備良好的晶型穩定性和化學穩定性，並且所用結晶溶劑低毒低殘留，可更好地用於臨床治療。
