A method of manufacturing a needle-like array sheet includes supplying a first needle-like array-forming solution consisting of an aqueous solution on a first mold having a first recess； interrupting drying in a wet state and forming a needle-like distal end part； supplying a second needle-like array-forming solution consisting of an aqueous solution on a second mold having a second recess； peeling a sheet part molding product, which is dried and solidified and has a protrusion corresponding to the second recess, after the sheet part molding product is formed； inserting the protrusion of the sheet part molding product into the first recess of the first mold； drying and solidifying the needle-like distal end part and the sheet part molding product after inserting the protrusion, bonding the needle-like distal end part and the protrusion of the sheet part molding product together, and forming a needle-like array sheet having the needle-like array.
