A vessel wound closure system (100) comprising:an introducer (110)an outer sheath (120) slidably disposed through the introducer (110) and having a proximal first position, a distal second position at, or beyond, a distal end of the introducer, and a partially withdrawn third postionan inner sheath (130) slidably disposed through the outer sheath (120) and having a proximal first position, and a distal second position at, or beyond, a distal end of the outer sheath in the third positiona handle (140) associated with the outer sheath and the inner sheatha plunger (150) extending through the handle (150)a sealing member (170) configured to deploy from a distal end of the outer sheath (120) when the outer sheath is in the third positionan anchor member (180) configured to deploy from a distal end of the inner sheath (130) by depression of the plunger (150) anda suture (160) connecting the sealing member (170) with the anchor member (180).