PROBLEM TO BE SOLVED: To provide an antibody that specifically binds to human ADAM28, inhibits enzyme activity of human ADAM28, and has an activity to suppress metastasis of a cancer cell that expresses human ADAM28.SOLUTION: An antibody comprises a light chain variable region and a heavy chain variable region, wherein the light chain variable region comprises CDR1, CDR2 and CDR3 each having a specific amino acid sequence, and the heavy chain variable region comprises CDR1, CDR2 and CDR3 each having a specific amino acid sequence.SELECTED DRAWING: None【課題】ヒトADAM28に特異的に結合し、ヒトADAM28の酵素活性を阻害し、ヒトADAM28を発現する癌細胞の転移を抑制する活性を有する抗体を提供すること。【解決手段】軽鎖可変領域及び重鎖可変領域を含む抗体であって、軽鎖可変領域が、それぞれ特定のアミノ酸配列を有するCDR1、CDR2及びCDR3を含み、且つ、重鎖可変領域が、それぞれ特定のアミノ酸配列を有するCDR1、CDR2及びCDR3を含むことを特徴とする抗体。【選択図】なし