The invention relates to a medical instrumentation, comprising a hand-held, integrated, medical navigation system which comprises an optical detection unit having a camera, a data processing unit and an optical display unit, the data processing unit being coupled to the detection unit and the display unit, it being possible for location and/or orientation data of a medical marking device which is detectable with the detection unit to be processed by the data processing unit and information relating thereto to be represented on the display unit, the instrumentation comprising an illumination unit with which light is emittable in the direction of the marking device detectable with the detection unit.