Inhibition par ARNi des conditions liées au Facteur de nécrose tumorale alpha

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专利权人:

ALCON RESEARCH; LTD.

发明人:

申请号：

EP07797553.0

公开号：

EP2018426B1

申请日:

2007.05.17

申请国别(地区):

EP

年份:

2013

代理人:

摘要：

RNA interference is provided for inhibition of tumor necrosis factor &alpha； (TNF&alpha；) by silencing TNF&alpha； cell surface receptor TNF receptor-1 (TNFR1) mRNA expression, or by silencing TNF&alpha； converting enzyme (TACE/ADAM17) mRNA expression. Silencing such TNF&alpha； targets, in particular, is useful for treating patients having a TNF&alpha；-related condition or at risk of developing a TNF&alpha；-related condition such as the ocular conditions dry eye, allergic conjunctivitis, or ocular inflammation, or such as dermatitis, rhinitis, or asthma, for example.

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