Michael Downes,Ruth T. Yu,Vihang A. Narkar,Ronald M. Evans
申请号：
US14972711
公开号：
US20160101086A1
申请日:
2015.12.17
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Disclosed herein are methods of improving muscular health, such as enhancing muscle regeneration, maintenance, or repair. In some examples, the method includes administering to the subject an effective amount of an agent capable of increasing activity or expression of estrogen receptor-related gamma (ERRγ), related receptors ERRα or β, or ERR-regulated metabolic and angiogenic genes, thereby enhancing muscle regeneration, maintenance, or repair. In some examples, the methods are utilized to treat a subject with one or more signs or symptoms of muscular dystrophy, such as, but not limited to Duchenne muscular dystrophy. In some examples, the disclosed methods further include selecting a subject in need of enhancing muscle regeneration, maintenance, or repair.
