AL-MAHMOOD, SALMAN,COLIN, SYLVIE,CONDUZORGUES, JEAN-PASCAL,VIAUD, ERIC
申请号：
CA2807858
公开号：
CA2807858A1
申请日:
2011.08.10
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
This invention relates to a pharmaceutical composition for the treatment and/or prevention of at least one pathological neovascularization-related conditions of the interior of the eye, the composition comprising a therapeutically effective amount of an antisens oligonucleotide having the sequence SEQ ID NO: 1: 5'-TCTCCGGAGGGCTCGCCATGCTGCT-3' or any function conservative sequence comprising from 9 to 30 nucleotides that has 75%, 80%, 85%, 90%, 95% or more than 95%, 96%, 97%, 98%, 99% of identity compared to SEQ ID NO: 1 and that conserves the capacity of inhibiting IRS-1 gene expression as SEQ ID NO: 1, and the composition being administered within the posterior segment of the eye to a subject in need thereof； this invention also relates to a method for treating a pathological neovascularization-related condition of the interior of the eye in a subject in need thereof comprising administering to the subject a therapeutically effective amount of said pharmaceutical composition.
