Described herein are thermoplastic denture frames having significantly improved lifetimes as well as comfort. The denture frames include a polymer composition including at least one poly(ether ether ketone) ("PEEK") polymer and at least one polyphenylsulfone ("PPSU") polymer. It was surprisingly discovered that the polymer compositions have significantly improved color stability, relative to corresponding polymer compositions including PEEK polymer as the only polymeric component of the polymer composition. Additionally, the polymer compositions have significantly improved toughness, flexibility and dimensional stability. The combination of the aesthetic characteristics and mechanical characteristics of the polymer compositions allows for denture frames having improved lifetimes and comfort.