Joseph P. Vacanti,Young-Moon M. Shin,Jennifer Ogilvie,Alexander Sevy,Tomoyuki Maemura,Osamu Ishii,Mohammad R. Kaazempur-Mofrad,Jeffrey T. Borenstein,Kevin R. King,Chiao-Chun Wang,Eli Weinberg
申请号：
US14153591
公开号：
US09738860B2
申请日:
2014.01.13
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick, structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.
