Particle therapy system (100) comprising a charged particle beam (6) generator (3), a beam transport system (4) and a beam delivery system (5) for irradiating the particle beam (6) according to a main beam axis (Z) to a target volume (1) to be treated. The system comprises an energy modulation filter (10), interposed transversally in the beam path between the generator (3) and the target volume (1) and comprising a plurality of individual filtering elements (21, 22, 23,... 31, 32, 33,...) which are arranged according to a two-dimensional (X,Y) grid. At least a first and a second filtering element (21, 22) are arranged according to the X direction and are adapted to generate respective distributions of particle energies at their respective outputs which are totally independent from each other. Furthermore, at least a third and a fourth filtering element (31, 32) are arranged according to the Y direction and are adapted to generate respective distributions of particle energies at their respective outputs which are totally independent from each other. Accordingly, a better depth-conformal irradiation of the target volume (1) can be achieved. Preferably, the therapy system (100) comprises scanning means (40) for scanning the particle beam (6) in the X and Y directions over the individual filtering elements of the energy filter (10). Hence a better lateral-conformal irradiation of the target volume (1) can be achieved.La présente invention concerne un système dhadronthérapie (100) comprenant un générateur (3) de faisceau de particules chargées (6), un système de transport de faisceau (4) et un système de délivrance de faisceau (5) pour irradier le faisceau de particules (6) en fonction dun axe principal de faisceau (Z) sur un volume source (1) à traiter. Le système comprend un filtre à modulation dénergie (10), interposé transversalement dans la trajectoire du faisceau entre le générateur (3) et le volume cible (1) et comprenant une pluralité déléments filtrants individu