Scott A. Guelcher,Baek-Hee Lee,Ruijing Guo,Bing Li
申请号：
US13353257
公开号：
US20120183622A1
申请日:
2012.01.18
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Embodiments of the present invention comprise biodegradable composites including a polyurethane component and cells encapsulated in gel beads, as well as methods of making such composite and uses thereof. In certain embodiments the gel beads are alginate beads. The composites may be moldable and/or injectable. After implantation or injection, a composition may be set to form a porous composite that provides mechanical strength, supports the in-growth of cells, and/or delivers cells to particular tissues. Inventive composites have the advantage of being able to fill irregularly shaped implantation sites, deliver cells in a localized and noninvasive manner, and optimize cell proliferation and differentiation of delivered cells.
